The prothrombin G20210A mutation is a risk factor for sudden hearing loss in young patients.
نویسندگان
چکیده
6. Warner D, Mansfield MW, Grant PJ. Coagulation factor XIII and cardiovascular disease in UK Asian patients undergoing coronary angiography. Thromb Haemost 2001; 85: 408-11. 7. Kohler HP, Grant PJ. Clustering of haemostatic risk factors with FXIIIVal34Leu in patients with myocardial infarction. Thromb Haemost 1998; 80: 862. 8. Ariëns RAS, Kohler HP, Mansfield MW, Grant PJ. Subunit antigen and activity levels of coagulation factor XIII in healthy individuals: relationship to gender, age, smoking and hypertension. Arterioscl Thromb Vasc Biol 1999; 19: 2012-6. 9. Kohler HP, Stickland MH, Ossei-Gerning N, Carter A, Mikkola H, Grant PJ. Association of a common polymorphism in the factor XIII gene with myocardial infarction. Thromb Haemost 1998; 79: 8-13.
منابع مشابه
Factor V Leiden, MTHFR C677T and Prothrombin Gene Mutation G20210A in Iranian Patients with Venous Thrombosis
Background: Factor V Leiden, Prothrombin gene (G20210A) and MTHFR (C677T) polymorphism are the main biomarkers for evaluation of tendency for venous thromboembolism. We aimed to investigate the frequency of mutations in factor V Leiden, Prothrombin G20210A and MTHFR C677T and identify the genetic status for these mutations in patients with venous thrombosis. Methods: This study was carried out...
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Normal hemostasis requires balanced regulation of prothrombotic and antithrombotic factors. Inherited alteration of factor V and prothrombin gene, the G20210A mutation, increases the resistance of factor V to degradation and booster production of prothrombin respectively. These alterations can increase hypercoagulability leading to thrombotic consequences. We aimed to assess the frequencies of ...
متن کامل[A Meta-analysis of prothrombin G20210A polymorphism and its risk for sudden sensorineural hearing loss].
OBJECTIVE To investigate the correlation between prothrombin G20210A polymorphism and the risk for idiopathic sudden sensorineural hearing loss (ISSNHL) using Meta-analysis methodology. METHODS Databases, including PUBMED, EMBASE, Cochrane Library and CBM, were searched to collect the case control studies on the correlation between prothrombin G20210A polymorphism and idiopathic sudden sensor...
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Background & Aims:Thromboembolism is an acute cardiovascular disease that ranges from clinically unimportant to massive embolism. Both acquired and hereditary risk factors contribute to the disease. We aimed to determine the prevalence of two hereditary predisposing factor of the disease, prothrombin G20210A and factor V Leiden (G1691A) polymorphisms, in Kerman population.<br /...
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Background and purpose: Beside the environmental determinants there are major genetic factors that could cause Myocardial Infarction (MI). The aim of this study was to clarify the relationship between factor V Leiden and prothrombin G20210A with acute MI in patients younger than 50 years of age. Materials and methods: In this case-control study we recruited 101 MI patients and 101 healthy ...
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Background & Aims: Preeclampsia is one of the complications of pregnancy and a major cause of maternal mortality. Since, hypercoagulation is one of the risk factors, defined polymorphisms of V and II coagulation factors (G1691A and G20210A) may increase the risk of the disease. Methods: This investigation was performed on blood samp...
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ورودعنوان ژورنال:
- Thrombosis and haemostasis
دوره 86 4 شماره
صفحات -
تاریخ انتشار 2001